I want to give an honest summary of the medical literature because most of what circulates online is anecdote or marketing. Here's what peer-reviewed research actually shows:
PILLS/SUPPLEMENTS: No peer-reviewed evidence for permanent structural enhancement from any oral supplement. Blood flow supplements have evidence for erection quality improvement. That's it.
TOPICAL CREAMS: No peer-reviewed evidence for permanent structural enhancement. Vasodilating compounds have evidence for temporary engorgement. Collagen peptide topicals have skin quality evidence. Penile tissue-specific studies absent.
PEPTIDES: Cell culture and animal studies only for most. PT-141 has human clinical evidence for sexual function. BPC-157 has animal healing evidence. Enhancement application for all — no formal human studies.
PHYSICIAN-ADMINISTERED FILLER: Multiple published case series and clinical studies showing consistent, measurable girth increase with good safety profiles. This is the only non-surgical approach with actual clinical evidence for meaningful enhancement.
— ClinicalCarlos